N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility

  title={N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility},
  author={Scott B. Snapper and Fuminao Takeshima and In{\'e}s Mar{\'i}a Ant{\'o}n and Ching-Hui Liu and Sheila M. Thomas and Deanna Nguyen and Darryll D. Dudley and H. B. Fraser and Daniel Lee Purich and Marco L{\'o}pez-Ilasaca and Christoph Klein and Laurie Davidson and Roderick Bronson and Richard C. Mulligan and Fred Southwick and Raif Geha and Marcia B. Goldberg and Fred S. Rosen and John H. Hartwig and Frederick W Alt},
  journal={Nature Cell Biology},
The Wiskott–Aldrich syndrome protein (WASP) family of molecules integrates upstream signalling events with changes in the actin cytoskeleton. N-WASP has been implicated both in the formation of cell-surface projections (filopodia) required for cell movement and in the actin-based motility of intracellular pathogens. To examine N-WASP function we have used homologous recombination to inactivate the gene encoding murine N-WASP. Whereas N-WASP-deficient embryos survive beyond gastrulation and… CONTINUE READING
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