N-Sulfonyl homoserine lactones as antagonists of bacterial quorum sensing.

  title={N-Sulfonyl homoserine lactones as antagonists of bacterial quorum sensing.},
  author={Sandra Castang and Bernard Chantegrel and Christian Deshayes and Ren{\'e} Dolmazon and Patrice Gouet and Richard Haser and Sylvie Reverchon and William Nasser and Nicole Hugouvieux-Cotte-Pattat and Alain Doutheau},
  journal={Bioorganic & medicinal chemistry letters},
  volume={14 20},
A series of 11 new analogues of N-acylhomoserine lactones in which the carboxamide bond was replaced by a sulfonamide one, has been synthesised. These compounds were evaluated for their ability to competitively inhibit the action of 3-oxohexanoyl-L-homoserine lactone, the natural ligand of the quorum sensing transcriptional regulator LuxR, which in turn activates expression of bioluminescence in the model bacterium Vibrio fischeri. Several compounds were found to display antagonist activity… CONTINUE READING

From This Paper

Topics from this paper.
18 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 18 extracted citations

Similar Papers

Loading similar papers…