• DOI:10.1038/sj.npp.1300585
Corpus ID: 24217984

N-Substituted Piperazines Abused by Humans Mimic the Molecular Mechanism of 3,4-Methylenedioxymethamphetamine (MDMA, or ‘Ecstasy’)

@article{Baumann2005NSubstitutedPA,
  title={N-Substituted Piperazines Abused by Humans Mimic the Molecular Mechanism of 3,4-Methylenedioxymethamphetamine (MDMA, or ‘Ecstasy’)},
  author={M. Baumann and R. D. Clark and Allison G Budzynski and J. Partilla and B. Blough and R. Rothman},
  journal={Neuropsychopharmacology},
  year={2005},
  volume={30},
  pages={550-560}
}

• M. Baumann, R. D. Clark, +3 authors R. Rothman
• Published 2005
• Chemistry, Medicine
• Neuropsychopharmacology

3,4-Methylenedioxymethamphetamine (MDMA, or ‘Ecstasy’) is an illicit drug that stimulates the release of serotonin (5-HT) and dopamine (DA) from neurons. Recent evidence reveals that drug users are ingesting piperazine analogs, like 1-benzylpiperazine (BZP, or ‘A2’) and 1-(m-trifluoromethylphenyl)piperazine (TFMPP, or ‘Molly’), to mimic psychoactive effects of MDMA. In the present study, we compared the neurochemistry of MDMA, BZP, and TFMPP in rats. The effects of MDMA, BZP, and TFMPP on… Expand