N-Propionylmannosamine-induced over-expression and secretion of thioredoxin leads to neurite outgrowth of PC12 cells.
@article{Horstkorte2010NPropionylmannosamineinducedOA, title={N-Propionylmannosamine-induced over-expression and secretion of thioredoxin leads to neurite outgrowth of PC12 cells.}, author={Rùˆdiger Horstkorte and Stefan Reinke and Christian H. Bauer and Werner Reutter and Maria Kontou}, journal={Biochemical and biophysical research communications}, year={2010}, volume={395 3}, pages={ 296-300 } }
17 Citations
N-Propionylmannosamine stimulates axonal elongation in a murine model of sciatic nerve injury
- BiologyNeural regeneration research
- 2015
The biochemical glycoengineering of the N-acyl side chain of sialic acid might be a promising approach for improving peripheral nerve regeneration.
In vivo stimulation of early peripheral axon regeneration by N-propionylmannosamine in the presence of polysialyltransferase ST8SIA2
- Biology, ChemistryJournal of Neural Transmission
- 2015
The results demonstrate that the application of ManNProp has beneficial effects on early peripheral nerve regeneration and indicate that the stimulation of axon growth depends on ST8SIA2 activity in the nerve graft.
Stimulation of human peripheral blood mononuclear cells by the sialic acid precursor N-propanoylmannosamine
- Biology, ChemistryGlycoconjugate Journal
- 2013
The stimulation of PBMC by ManNProp might introduce a new approach of immunomodulation and cause a marked stimulation in the rate of proliferation ofPBMC.
Thioredoxin-2 Modulates Neuronal Programmed Cell Death in the Embryonic Chick Spinal Cord in Basal and Target-Deprived Conditions
- BiologyPloS one
- 2015
A cytoprotective effect of Trx2 on the programmed cell death (PCD) of neurons during spinal cord development and in a novel cultured spinal cord explant model is highlighted.
Activation of Rac1-dependent redox signaling is critically involved in staurosporine-induced neurite outgrowth in PC12 cells
- Biology, ChemistryFree radical research
- 2013
Results indicate that activation of Rac1, which leads to ROS generation, is required for neurite outgrowth induced by staurosporine in PC12 cells.
Identification of axon growth promoters in the secretome of the deer antler velvet
- BiologyNeuroscience
- 2017
Y-27632 Induces Neurite Outgrowth by Activating the NOX1-Mediated AKT and PAK1 Phosphorylation Cascades in PC12 Cells
- Biology, ChemistryInternational journal of molecular sciences
- 2020
It is suggested that Rac1/NOX1-dependent ROS generation and subsequent activation of the AKT/PAK1 cascade contribute to Y-27632-induced neurite outgrowth in PC12 cells.
Metabolic glycoengineering of mesenchymal stromal cells with N-propanoylmannosamine.
- Biology, ChemistryGlycobiology
- 2013
The present results represent the first structural analysis of an N-glycome of ManNProp-supplemented cells and demonstrate the feasibility of modifying cell surface glycosylation of therapeutic cells by this type of metabolic glycoengineering.
Tissue-based metabolic labeling of polysialic acids in living primary hippocampal neurons
- Biology, ChemistryProceedings of the National Academy of Sciences
- 2015
A reliable and cytocompatible method for in vitro analysis of glycans complementary to the conventional cell-based metabolic labeling for chemical glycobiology is suggested.
Axonal protection by thioredoxin-1 with inhibition of interleukin-1β in TNF-induced optic nerve degeneration.
- Biology, MedicineExperimental eye research
- 2016
References
SHOWING 1-10 OF 34 REFERENCES
Critical Roles of Thioredoxin in Nerve Growth Factor-Mediated Signal Transduction and Neurite Outgrowth in PC12 Cells
- Biology, ChemistryThe Journal of Neuroscience
- 2003
It is shown that NGF induces TRX expression at protein and mRNA levels, and the results suggest that TRX plays a critical regulatory role in NGF-mediated signal transduction and outgrowth in PC12 cells.
Biochemical Engineering of Cell Surface Sialic Acids Stimulates Axonal Growth
- Biology, ChemistryThe Journal of Neuroscience
- 2002
It is hypothesized that transcription could be modulated by the unnatural CMP-N-propanoylneuraminic acid and that sialic acid activation might be a general tool to regulate cellular functions, such as neurite outgrowth.
Sialic acid metabolism is involved in the regulation of gene expression during neuronal differentiation of PC12 cells
- Biology, ChemistryGlycoconjugate Journal
- 2008
Evidence that the application of sialic acid a precursor modulates gene expression and cell differentiation is presented, and the first experimental data showing that the sIALic acid metabolism is closely associated with signal transduction and regulation of neuronal differentiation are shown.
Thioredoxin as a neurotrophic cofactor and an important regulator of neuroprotection
- Biology, ChemistryMolecular Neurobiology
- 2007
Thioredoxin appears to be a neurotrophic cofactor that augments the effect of NGF on neuronal differentiation and regeneration and acts also as a neuronal survival factor.
Apoptosis Induced by Withdrawal of Trophic Factors Is Mediated by p38 Mitogen-activated Protein Kinase*
- Biology, ChemistryThe Journal of Biological Chemistry
- 1997
The hypothesis that insulin promotes cell survival, at least in part, by inhibiting the p38 pathway is supported, and the role of p38 in cellular apoptosis is supported.
Neuroprotection by glial cells through adult T cell leukemia-derived factor/human thioredoxin (ADF/TRX)
- BiologyBrain Research
- 1994
Oxidative inactivation of thioredoxin as a cellular growth factor and protection by a Cys73-->Ser mutation.
- BiologyBiochemical pharmacology
- 1996
Lessons from GNE-deficient embryonic stem cells: sialic acid biosynthesis is involved in proliferation and gene expression.
- Biology, ChemistryGlycobiology
- 2010
It is found for the first time that proliferation is directly correlated with GNE-expression and the cellular sialic acid concentration, and identified growth-related genes that are differentially expressed in G NE-deficient embryonic stem cells compared to wild-type embryonic stem Cells.
Thioredoxin, a regulator of gene expression
- BiologyOncogene
- 2004
It is found that by regulation via Trx, cells are able to adapt to the prevailing redox conditions and is enlighten the pathophysiology of FA in the respect that the characteristic diminution of Trx that results in the dysregulation of gene expression is a basis for the major symptoms of this disease.
A Bifunctional Enzyme Catalyzes the First Two Steps in N-Acetylneuraminic Acid Biosynthesis of Rat Liver
- Biology, ChemistryThe Journal of Biological Chemistry
- 1997
The isolation and characterization of a cDNA clone encoding this bifunctional enzyme is reported, which contains exact matches of the sequences of five peptides derived from tryptic cleavage of the enzyme.