N-O tethered carbenoid cyclopropanation facilitates the synthesis of a functionalized cyclopropyl-fused pyrrolidine.

@article{Kalia2013NOTC,
  title={N-O tethered carbenoid cyclopropanation facilitates the synthesis of a functionalized cyclopropyl-fused pyrrolidine.},
  author={Dimpy Kalia and G{\"o}kçe Merey and Min Guo and Herman O. Sintim},
  journal={The Journal of organic chemistry},
  year={2013},
  volume={78 12},
  pages={6131-42}
}
We report a facile approach to a cyclopropyl-fused pyrrolidine, which contains four stereogenic centers, by employing the N-O tethered carbenoid methodology. The synthesis was facilitated by the development of a direct Mitsunobu reaction of alcohols with N-alkyl-N-hydroxyl amides to give diazo precursors, which upon intramolecular cyclopropanation yielded a… CONTINUE READING