N-Myc overexpression leads to decreased β1 integrin expression and increased apoptosis in human neuroblastoma cells

@article{Golen2003NMycOL,
  title={N-Myc overexpression leads to decreased β1 integrin expression and increased apoptosis in human neuroblastoma cells},
  author={Cynthia M van Golen and Mary E. Soules and Alyssa R Grauman and Eva L. Feldman},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={2664-2673}
}
Neuroblastoma is a childhood tumor thought to arise through improper differentiation of neural crest cells. Increased N-Myc expression in neuroblastoma indicates highly malignant disease and poor patient prognosis. N-myc enhances cell growth, insulin-like growth factor type I receptor (IGF-IR) expression, and tumorigenicity in combination with Bcl-2. Despite these effects, N-Myc overexpression in SHEP neuroblastoma cells (SHEP/N-Myc cells) increases serum-withdrawal and mannitol-induced… CONTINUE READING

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Neuroblastoma and MYCN.

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  • 2013
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