N-Myc expression enhances the oncolytic effects of vesicular stomatitis virus in human neuroblastoma cells

@inproceedings{Corredor2016NMycEE,
  title={N-Myc expression enhances the oncolytic effects of vesicular stomatitis virus in human neuroblastoma cells},
  author={Juan Carlos Corredor and Nicole Redding and Karen Blot{\'e} and Stephen M. Robbins and Donna L. Senger and John Cameron Bell and Paul Beaudry},
  booktitle={Molecular therapy oncolytics},
  year={2016}
}
N-myc oncogene amplification is associated but not present in all cases of high-risk neuroblastoma (NB). Since oncogene expression could often modulate sensitivity to oncolytic viruses, we wanted to examine if N-myc expression status would determine virotherapy efficacy to high-risk NB. We showed that induction of exogenous N-myc in a non-N-myc-amplified cell line background (TET-21N) increased susceptibility to oncolytic vesicular stomatitis virus (mutant VSVΔM51) and alleviated the type I IFN… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 72 references

Similar Papers

Loading similar papers…