N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer.

@article{Dardenne2016NMycIA,
  title={N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer.},
  author={Etienne Dardenne and Himisha Beltran and Matteo Benelli and Kaitlyn M. Gayvert and Adeline Berger and Loredana Puca and Joanna Cyrta and Andrea Sboner and Zohal Noorzad and Theresa Macdonald and Cynthia Cheung and Ka Shing Yuen and Dong Gao and Yu Chen and Martin Eilers and Juan-Miguel Mosquera and Brian Robinson and Olivier Elemento and Mark A. Rubin and Francesca Demichelis and David S. Rickman},
  journal={Cancer cell},
  year={2016},
  volume={30 4},
  pages={563-577}
}
The transition from castration-resistant prostate adenocarcinoma (CRPC) to neuroendocrine prostate cancer (NEPC) has emerged as an important mechanism of treatment resistance. NEPC is associated with overexpression and gene amplification of MYCN (encoding N-Myc). N-Myc is an established oncogene in several rare pediatric tumors, but its role in prostate cancer progression is not well established. Integrating a genetically engineered mouse model and human prostate cancer transcriptome data, we… CONTINUE READING
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