N-Methyl and peptoid scans of an autoinducing peptide reveal new structural features required for inhibition and activation of AgrC quorum sensing receptors in Staphylococcus aureus.

@article{TalGan2014NMethylAP,
  title={N-Methyl and peptoid scans of an autoinducing peptide reveal new structural features required for inhibition and activation of AgrC quorum sensing receptors in Staphylococcus aureus.},
  author={Yftah Tal-Gan and Danielle M Stacy and Helen E Blackwell},
  journal={Chemical communications},
  year={2014},
  volume={50 23},
  pages={3000-3}
}
We report the first N-methyl and peptoid residue scans of a full-length autoinducing peptide (AIP), AIP-III, used by Staphylococcus aureus for quorum sensing (QS). Biological evaluation of these AIP-III analogues uncovered new features of the AIP-III scaffold that can be tuned to develop chemical probes of QS in all four groups of S. aureus (I-IV). 

From This Paper

Topics from this paper.
3 Citations
10 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 10 references

and H

  • Y. Tal-Gan, D. M. Stacy, M. K. Foegen, D. W. Koeni
  • E. 105 Blackwell, J. Am. Chem. Soc.,
  • 2013
Highly Influential
4 Excerpts

Chem

  • M. Thoendel, J. S. Kavanaugh, C. E. Flack, A. R. Horswill
  • Rev.,
  • 2011

Proc

  • J. R. Li, W. L. Wang, S. X. Xu, N. A. Magarvey, J. K. McCormick
  • Natl. Acad. Sci. U. S. A.,
  • 2011

Nat

  • H. F. Chambers, F. R. DeLeo
  • Rev. Microbiol.,
  • 2009
1 Excerpt

Annu

  • R. P. Novick, E. Geisinger
  • Rev. Genet.,
  • 2008
1 Excerpt

Org

  • S. A. Fowler, D. M. Stacy, H. E. Blackwell
  • Lett.,
  • 2008

and T

  • E. A. Georg
  • W. Muir, ChemBioChem,
  • 2007
1 Excerpt

Mol

  • P. McDowell, Z. Affas, +9 authors P. Williams
  • Microbiol.,
  • 2001

J

  • S. Jarraud, G. J. Lyon, +5 authors R. P. Novick
  • Bacteriol.,
  • 2000

and R

  • G. Ji, R. Beavi
  • P. Novick, Science,
  • 1997

Similar Papers

Loading similar papers…