N-Methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA

@article{Jaiswal2003NMethylNnitroNnitrosoguanidineindu,
  title={N-Methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA},
  author={Aruna Shanker Jaiswal and Asha S Multani and Sen Pathak and Satya T Narayan},
  journal={Molecular Cancer},
  year={2003},
  volume={3},
  pages={3 - 3}
}
Cellular senescence is a state in which mammalian cells enter into an irreversible growth arrest and altered biological functions. The senescence response in mammalian cells can be elicited by DNA-damaging agents. In the present study we report that the DNA-damaging agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) is able to induce senescence in the HCT-116 colon cancer cell line. Cells treated with lower concentrations of MNNG (0–25 microM) for 50 h showed a dose-dependent increase in G2/M… CONTINUE READING

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The subcellular destinations of apc proteins

Nature Reviews Molecular Cell Biology • 2002
View 4 Excerpts
Highly Influenced

Live or let die: the cell's response to p53

Nature Reviews Cancer • 2002
View 3 Excerpts

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