N-Methyl-D-aspartate receptor blockade induces neuronal apoptosis in cortical culture.

@article{Hwang1999NMethylDaspartateRB,
  title={N-Methyl-D-aspartate receptor blockade induces neuronal apoptosis in cortical culture.},
  author={J Y Hwang and Yong Ho Kim and Young Hwan Ahn and Myung Bok Wie and Jae Young Koh},
  journal={Experimental neurology},
  year={1999},
  volume={159 1},
  pages={124-30}
}
Whereas excessive activation of the NMDA receptor may contribute to ischemic neuronal injury, physiologic activation may promote neuronal survival under certain conditions. Consistently, it has recently been shown that NMDA antagonists induce apoptosis of central neurons in immature rats. In the present study, we have examined whether NMDA antagonists induce neuronal apoptosis also in a culture condition. Exposure of cortical cultures (DIV 10-13) to MK-801 (1-10 microM) for 48 h resulted in… CONTINUE READING