N-Methyl-D-aspartate receptor antagonists disrupt the formation of a mammalian neural map ( retinocoflicular projection / visual system development / axon elimination / retinal ganglion cells / topographic maps )

@inproceedings{Simon2004NMethylDaspartateRA,
  title={N-Methyl-D-aspartate receptor antagonists disrupt the formation of a mammalian neural map ( retinocoflicular projection / visual system development / axon elimination / retinal ganglion cells / topographic maps )},
  author={David K Simon and GLEN T. PRUSKYt and Dennis D. M. O'Leary and MARTHA CONSTANTINE-PATONt},
  year={2004}
}
  • David K Simon, GLEN T. PRUSKYt, +1 author MARTHA CONSTANTINE-PATONt
  • Published 2004
The topographic ordering of retinal connections in the rat superior colliculus emerges during early postnatal Ilfe from an initially diffuse projection. Disruption of N-methyl-D-aspartate (NMDA) receptor activity in the superior colliculus during this period interferes with map remodeling. In rats chronically treated with NMDA receptor antagonists during the first two postnatal weeks, aberrant axons remain and arborize at topographically incorrect sites. These results indicate that, at a stage… CONTINUE READING