N-Methyl-D-aspartate receptor antagonist MK-801 attenuates morphine tolerance and associated glial fibrillary acid protein up-regulation: a proteomic approach.


BACKGROUND It is well known that long-term morphine administration results in tolerance, which limits the clinical use of this drug in pain management. METHODS Male Wistar rats were randomly assigned to receive one of four different infusions: morphine [15 microg/h, intrathecal (i.t.)], saline, MK-801 (5 microg/h, i.t.) plus morphine (15 microg/h, i.t… (More)
DOI: 10.1111/j.1399-6576.2008.01605.x


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