N-Methyl-D-aspartate receptor activation inhibits protein synthesis in cortical neurons independently of its ionic permeability properties.

@article{Gauchy2002NMethylDaspartateRA,
  title={N-Methyl-D-aspartate receptor activation inhibits protein synthesis in cortical neurons independently of its ionic permeability properties.},
  author={Christian Gauchy and Angus C. Nairn and Jacques Glowinski and Jo{\"e}l Pr{\'e}mont},
  journal={Neuroscience},
  year={2002},
  volume={114 4},
  pages={859-67}
}
Transient cerebral ischemia, which is accompanied by a sustained release of glutamate, strongly depresses protein synthesis. We have previously demonstrated in cortical neurons that a glutamate-induced increase in intracellular Ca(2+) is likely responsible for the blockade of the elongation step of protein synthesis. In this study, we provide evidence… CONTINUE READING