N-Glycosylation is not a prerequisite for glutamate receptor function but Is essential for lectin modulation.

@article{Everts1997NGlycosylationIN,
  title={N-Glycosylation is not a prerequisite for glutamate receptor function but Is essential for lectin modulation.},
  author={Inga Everts and Carmen Villmann and Michael Hollmann},
  journal={Molecular pharmacology},
  year={1997},
  volume={52 5},
  pages={
          861-73
        }
}
All ionotropic glutamate receptor (iGluR) subunits analyzed so far are heavily N-glycosylated at multiple sites on their amino-terminal extracellular domains. Although the exact functional significance of this glycosylation remains to be determined, it has been suggested that N-glycosylation may be a precondition for the formation of functional ion channels. In particular, it has been argued that N-glycosylation is required for the formation of functional ligand binding sites. We analyzed… CONTINUE READING

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