N-Glycosyl-thiophene-2-carboxamides: synthesis, structure and effects on the growth of diverse cell types.

Abstract

A range of N-glycosyl-thiophene-2-carboxamides, including a 6H-thieno[2,3-c]pyridin-7-one and a bivalent compound, have been synthesised and assayed for their effects on DNA synthesis in bovine aortic endothelial cells or on the growth of synoviocytes. Per-O-acetylated analogues of the glycoconjugates were significantly more effective inhibitors when… (More)

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Cite this paper

@article{Rawe2006NGlycosylthiophene2carboxamidesSS, title={N-Glycosyl-thiophene-2-carboxamides: synthesis, structure and effects on the growth of diverse cell types.}, author={Sarah L Rawe and Dearbhla Doyle and Violeta Zaric and Isabel Rozas and Kevin W. McMahon and Manuela Tosin and Helge M{\"{u}ller Bunz and Evelyn Patricia Murphy and Kathy M O' Boyle and Paul V Murphy}, journal={Carbohydrate research}, year={2006}, volume={341 10}, pages={1370-90} }