N-Glycans in cancer progression.

  title={N-Glycans in cancer progression.},
  author={Ken Tse-yau Lau and J. W. Dennis},
  volume={18 10},
N-Glycan branching in the medial-Golgi generates ligands for lattice-forming lectins (e.g., galectins) that regulate surface levels of glycoproteins including epidermal growth factor (EGF) and transforming growth factor-beta (TGF-beta) receptors. Moreover, functional classes of glycoproteins differ in N-glycan multiplicities (number of N-glycans/peptide), a genetically encoded feature of glycoproteins that interacts with metabolic flux (UDP-GlcNAc) and N-glycan branching to differentially… CONTINUE READING


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Control of tumor metabolism and growth by N-glycan processing

  • R Mendelsohn, P Cheung, +4 authors JW. Dennis
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