N-Glycans attached to the stem domain of haemagglutinin efficiently regulate influenza A virus replication.

@article{Wagner2002NGlycansAT,
  title={N-Glycans attached to the stem domain of haemagglutinin efficiently regulate influenza A virus replication.},
  author={Ralf Wagner and Dagmar Heuer and Thorsten Wolff and Astrid Herwig and Hans Dieter Klenk},
  journal={The Journal of general virology},
  year={2002},
  volume={83 Pt 3},
  pages={
          601-9
        }
}
The haemagglutinin (HA) protein of fowl plague virus A/FPV/Rostock/34 (H7N1) contains three N-linked oligosaccharide side chains in its stem domain. These stem glycans, which are attached to the Asn residues at positions 12, 28 and 478, are highly conserved throughout all HA protein sequences analysed to date. In a previous study, in which mutant HA proteins lacking individual stem glycosylation sites had been expressed from an SV-40 vector, it was shown that these glycans maintain the HA… CONTINUE READING

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