N-Formyl peptide receptor ligation induces rac-dependent actin reorganization through Gbeta gamma subunits and class Ia phosphoinositide 3-kinases.

@article{Belisle2000NFormylPR,
  title={N-Formyl peptide receptor ligation induces rac-dependent actin reorganization through Gbeta gamma subunits and class Ia phosphoinositide 3-kinases.},
  author={Barbara E Belisle and Arie Abo},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 34},
  pages={26225-32}
}
The N-formyl peptide receptor is a G protein-coupled transmembrane receptor involved in stimulating a variety of differential responses in neutrophils including chemotaxis, degranulation, superoxide production, transcriptional activation, and actin reorganization. Although it is known that N-formyl-Met-Leu-Phe induces actin reorganization, the sequence of events from the receptor to the actin cytoskeleton is not well characterized. To study the signaling pathway from the N-formyl peptide… CONTINUE READING