N-Difluoromethylthiophthalimide: A Shelf-Stable, Electrophilic Reagent for Difluoromethylthiolation.

@article{Zhu2015NDifluoromethylthiophthalimideAS,
  title={N-Difluoromethylthiophthalimide: A Shelf-Stable, Electrophilic Reagent for Difluoromethylthiolation.},
  author={Dianhu Zhu and Yang Gu and Long Lu and Qilong Shen},
  journal={Journal of the American Chemical Society},
  year={2015},
  volume={137 33},
  pages={10547-53}
}
A new, electrophilic difluoromethylthiolating reagent N-difluoromethylthiophthalimide 3 was developed. Reagent 3 can be readily synthesized in four steps from easily available starting materials phthalimide and TMSCF2H. N-difluoromethylthiophthalimide 3 is a powerful electrophilic difluoromethylthiolating reagent that allows the difluoromethylthiolation of a wide range of nucleophiles including aryl/vinyl boronic acids, alkynes, amines, thiols, β-ketoesters, and oxindoles and electron-rich… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-3 of 3 references

Biomedical Aspects of Fluorine Chemistry

R. a Filler
Kodansha: Tokyo, • 2014

Selected examples for the difluoromethylation of thiolates

Q.-Y. Chen, S.-W. Wu
J. Fluorine Chem • 1989

Selected examples for the difluoromethylation of thiolates : a )

Q.-Y. Chen, S.-W. Wu
J . Fluorine Chem . • 1988

Similar Papers

Loading similar papers…