N-Desmethylclozapine: Is There Evidence for its Antipsychotic Potential?

  title={N-Desmethylclozapine: Is There Evidence for its Antipsychotic Potential?},
  author={M. Mendoza and J. Lindenmayer},
  journal={Clinical Neuropharmacology},
  • M. Mendoza, J. Lindenmayer
  • Published 2009
  • Psychology, Medicine
  • Clinical Neuropharmacology
  • Objective:N-Desmethylclozapine (NDMC), one of clozapine's major metabolites, has become a recent focus of study for both its antipsychotic and metabolic effects. The aim of this review is to examine NDMC's biological activity in the context of the pathophysiology of schizophrenia and to critically evaluate the few recent preclinical and clinical studies of NDMC's potential antipsychotic effects to predict its therapeutic potential. Results:We review the complex interaction between clozapine and… CONTINUE READING
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