N-Dephenylated and N-phenyl urinary metabolites of mociprazine (CERM 3517) in beagle dogs after oral administration. A mass spectrometric determination

  title={N-Dephenylated and N-phenyl urinary metabolites of mociprazine (CERM 3517) in beagle dogs after oral administration. A mass spectrometric determination},
  author={A Enreille and J. F. Pognat and M. J. Galmter and C. Larttgue-Mattei and Jean Louis Chabard and Norbert Busch and J. A. Berger},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
SummaryCERM 3S17 (mociprazine), a new anti-emetic compound, was administered orally to six beagle dogs at 10 mg/kg b.i.d. for four days. Unconjugated urinary metabolites were identified by GC-MS analysis against synthesized reference compounds, after solvent extraction, purification by TLC and concentration. Twenty one metabolites were identified indicating the following biotransformations: N-dephenylation followed by reactions on the exposed secondary amine such as methylation and acetylation… 


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