N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso.

@article{Yoon2003NCoRMD,
  title={N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso.},
  author={Ho-Geun Yoon and Doug W. Chan and Albert B. Reynolds and Jun Qin and Jiemin Wong},
  journal={Molecular cell},
  year={2003},
  volume={12 3},
  pages={723-34}
}
The identification and characterization of molecular mechanisms utilized by cells to mediate transcriptional repression at methylated loci are fundamental to understanding the biological consequences of DNA methylation. Here we demonstrate that Kaiso, a methyl CpG binding protein belonging to the BTB/POZ family of transcription factors, is a component of the human N-CoR complex. In vitro, the Kaiso/N-CoR complex binds specific CpG-rich sequences in a methylation-dependent manner. In vivo, Kaiso… CONTINUE READING
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