A 52-year-old female patient with a past history of alcohol consumption (> 100 g/ethanol per day) was admitted in 2005 suffering from severe upper gastrointestinal bleeding with hemodynamic deterioration. After admission, she was treated with somatostatine (6 mg/24 h), and an urgent gastroscopy was performed. This revealed active jet bleeding from a big fundal varix (Fig. 1). An elastic rubber band was placed that initially controlled the bleeding. However, 48 hours later, the area was checked and the varix was sclerosed (Fig. 2) with 4 ml of N-butyl-2-cyanoacrylate (Glubran 2). The patient needed transfusion with four red-blood-cell concentrates and was transferred to the Intensive Care Unit (ICU). There was no evidence of digestive rebleeding and the patient was discharged after 14 days. Three months later, a follow-up gastroscopy was performed that showed no bleeding, but the varix was sclerosed again with 3 ml of N-butyl-2-cyanoacrylate. Over the following years the patient refused to undergo further follow-up gastroscopies, and quit drinking alcohol. She was admitted in July 2008 for hemorrhoidal bleeding and secondary iron deficiency anemia. At this point, the patient gave her consent to a gastroscopic examination, which showed the cyanoacrylate plug in good condition (Fig. 3) and no bleeding. A colonoscopy established that the cause of anemia was bleeding from the rectal venous plexus. During this period of time, liver function tests had improved due to alcohol withdrawal, and ultrasonophic follow-up detected no liver nodes.