N-Arachidonyl-glycine inhibits the glycine transporter, GLYT2a.

  title={N-Arachidonyl-glycine inhibits the glycine transporter, GLYT2a.},
  author={Amy L Wiles and Rhonda-Jo Pearlman and Mari Rosvall and Karin R. Aubrey and Robert J Vandenberg},
  journal={Journal of neurochemistry},
  volume={99 3},
N-arachidonyl-glycine is one of a series of N-arachidonyl-amino acids that are derived from arachidonic acid. N-arachidonyl-glycine is produced in a wide range of tissues with greatest abundance in the spinal cord. Here we report that N-arachidonyl-glycine is a reversible and non-competitive inhibitor of glycine transport by GLYT2a, but has little effect on glycine transport by GLYT1b or gamma-amino butyric acid transport by GAT1. It has previously been reported that the activity of GLYT2a is… CONTINUE READING
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