N-Acylhydrazones as drugs.

@article{Thota2018NAcylhydrazonesAD,
  title={N-Acylhydrazones as drugs.},
  author={S. Thota and D. A. Rodrigues and P. S. M. Pinheiro and L. M. Lima and C. A. M. Fraga and E. Barreiro},
  journal={Bioorganic \& medicinal chemistry letters},
  year={2018},
  volume={28 17},
  pages={
          2797-2806
        }
}
Over the last two decades, N-acylhydrazone (NAH) has been proven to be a very versatile and promising motif in drug design and medicinal chemistry. Herein, we discuss the current and future challenges in the emergence of bioactive NAH-based scaffolds and to developing strategies to overcome the failures in drug discovery. The NAH-related approved drugs nitrofurazone, nitrofurantoin, carbazochrome, testosterone 17-enanthate 3-benzilic acid hydrazine, nifuroxazide, dantrolene, and azumolene are… Expand
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