N-Acylethanolamines in human reproductive fluids.

  title={N-Acylethanolamines in human reproductive fluids.},
  author={Herbert Schuel and Lani Johnson Burkman and Jack Lippes and Kent Crickard and Ellyn Forester and Daniele Piomelli and Andrea Giuffrida},
  journal={Chemistry and physics of lipids},
  volume={121 1-2},
N-Acylethanolamines (NAEs) are an important family of lipid-signaling molecules. Arachidonylethanolamide (anandamide) (AEA), palmitoylethanolamide (PEA), and oleoylethanolamide (OEA) are co-produced from similar phospholipid precursors when neurons are stimulated. AEA is an endogenous agonist (endocannabinoid) for cannabinoid receptors. It binds with higher affinity to type CB1 than to type CB2 cannabinoid receptors. PEA does not bind to CB1, while the hypothesis that it reacts with putative… CONTINUE READING


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