N-Acyl-3-amino-5H-furanone derivatives as new inhibitors of LuxR-dependent quorum sensing: Synthesis, biological evaluation and binding mode study.

Abstract

New N-acyl homoserine lactone analogues, N-acyl-3-amino-5H-furanone derivatives and some 4-halogeno counterparts, were synthesised and tested for their ability to modulate LuxR-dependent bacterial quorum sensing. Both types of analogues proved to be inhibitors, the halogenated compounds being significantly more active. Molecular modelling suggested that the… (More)
DOI: 10.1016/j.bmcl.2008.06.090

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Cite this paper

@article{Estephane2008NAcyl3amino5HfuranoneDA, title={N-Acyl-3-amino-5H-furanone derivatives as new inhibitors of LuxR-dependent quorum sensing: Synthesis, biological evaluation and binding mode study.}, author={Jane Estephane and Julien Dauvergne and Laurent Soul{\`e}re and Sylvie Reverchon and Yves Queneau and Alain Doutheau}, journal={Bioorganic & medicinal chemistry letters}, year={2008}, volume={18 15}, pages={4321-4} }