N-Acetyltransferase 2: ultra-slow acetylators enter the stage

  title={N-Acetyltransferase 2: ultra-slow acetylators enter the stage},
  author={Silvia Selinski and Meinolf Blaszkewicz and Stephan Getzmann and Klaus Golka},
  journal={Archives of Toxicology},
of NAT2 in humans by the ratio of two caffeine metabolites in urine (Selinski et al. 2011). Recent in vivo studies indicate remarkable differences in the subgroup of slow acetylators leading to a differentiation between “ultra-slow” and “all other slow” acetylators (Selinski et al. 2013b; Ruiz et al. 2012). Ultra-slow acetylators are persons with two copies of the frequent NAT*6A haplotype and/or perhaps other infrequent haplotypes from the NAT2*6 (sharing rs1799930, G590A with *6A) cluster or… CONTINUE READING


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