N-Acetylmannosamine Improves Object Recognition and Hippocampal Cell Proliferation in Middle-Aged Mice

  title={N-Acetylmannosamine Improves Object Recognition and Hippocampal Cell Proliferation in Middle-Aged Mice},
  author={Takefumi Kikusui and Aki Shimozawa and Aya Kitagawa and Miho Nagasawa and Kazutaka Mogi and Shintaro Yagi and Kunio Shiota},
  journal={Bioscience, Biotechnology, and Biochemistry},
  pages={2249 - 2254}
Sialic acids may modulate cell proliferation and gene expression, particularly in neural cells in vitro. However, the function of sialic acids in the central nervous system has not previously been examined. We examined whether N-acetylmannosamine (ManNAc) could improve object recognition and hippocampal cell proliferations in middle-aged mice. C56BL/6J mice aged 52 weeks were treated with ManNAc for 4 weeks. Their cognitive-ability was assessed with a place and object recognition test. ManNAc… Expand
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