N-Acetylcysteine rapidly replenishes central nervous system glutathione measured via magnetic resonance spectroscopy in human neonates with hypoxic-ischemic encephalopathy

@article{Moss2018NAcetylcysteineRR,
  title={N-Acetylcysteine rapidly replenishes central nervous system glutathione measured via magnetic resonance spectroscopy in human neonates with hypoxic-ischemic encephalopathy},
  author={Hunter G Moss and T R Brown and Donald B. Wiest and Dorothea D. Jenkins},
  journal={Journal of Cerebral Blood Flow & Metabolism},
  year={2018},
  volume={38},
  pages={950 - 958}
}
  • Hunter G Moss, T R Brown, +1 author Dorothea D. Jenkins
  • Published 2018
  • Medicine, Biology
  • Journal of Cerebral Blood Flow & Metabolism
  • Persistent oxidative stress depletes reduced glutathione (GSH), an intracellular antioxidant and an important determinant of CNS injury after hypoxia ischemia. We used standard, short echo time Stimulated Echo Acquisition Mode (STEAM) to detect GSH by magnetic resonance spectroscopy (MRS) in 24 term neonates with hypoxic-ischemic encephalopathy (HIE), on day of life 5–6, after rewarming from therapeutic hypothermia. MRS demonstrated reliable, consistent GSH of 1·64 ± 0·20 mM in the basal… CONTINUE READING

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