N-Acetylcysteine protects against trichloroethene-mediated autoimmunity by attenuating oxidative stress.

@article{Wang2013NAcetylcysteinePA,
  title={N-Acetylcysteine protects against trichloroethene-mediated autoimmunity by attenuating oxidative stress.},
  author={Gangduo Wang and Jianling Wang and Huaxian Ma and G. A. Shakeel Ansari and Mahjabeen Khan},
  journal={Toxicology and applied pharmacology},
  year={2013},
  volume={273 1},
  pages={
          189-95
        }
}
Exposure to trichloroethene (TCE), a ubiquitous environmental contaminant, is known to induce autoimmunity both in humans and animal models. However, mechanisms underlying TCE-mediated autoimmunity remain largely unknown. Previous studies from our laboratory in MRL+/+ mice suggest that oxidative stress may contribute to TCE-induced autoimmune response. The current study was undertaken to further assess the role of oxidative stress in TCE-induced autoimmunity by supplementing with an antioxidant… CONTINUE READING
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