N-Acetylcysteine does not artifactually lower plasma creatinine concentration.

@article{Haase2008NAcetylcysteineDN,
  title={N-Acetylcysteine does not artifactually lower plasma creatinine concentration.},
  author={Michael V Haase and Anja Haase-Fielitz and Sujiva I Ratnaike and Michael C Reade and Sean M. Bagshaw and Stanislao Morgera and Duska Dragun and Rinaldo Bellomo},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2008},
  volume={23 5},
  pages={1581-7}
}
BACKGROUND All randomized controlled trials of N-acetylcysteine (NAC) in contrast media-induced nephropathy used creatinine as a marker of renal function. However, it has been suggested that NAC may lower plasma creatinine levels independent of any effects on glomerular filtration rate (GFR). METHODS At a tertiary hospital 110 cardiac surgical patients were randomly allocated to peri-operative infusion of NAC (300 mg/kg over 24 h, N = 30) or placebo (N = 80). We compared the plasma… CONTINUE READING

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