N-Acetylated alpha-linked acidic dipeptidase converts N-acetylaspartylglutamate from a neuroprotectant to a neurotoxin.

@article{Thomas2000NAcetylatedAA,
  title={N-Acetylated alpha-linked acidic dipeptidase converts N-acetylaspartylglutamate from a neuroprotectant to a neurotoxin.},
  author={Ajit G. Thomas and James J. Vornov and J. L. Olkowski and A T Merion and Barbara S Slusher},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2000},
  volume={295 1},
  pages={16-22}
}
We previously reported that inhibition of the brain enzyme N-acetylated alpha-linked acidic dipeptidase (NAALADase; glutamate carboxypeptidase II) robustly protects cortical neurons from ischemic injury. Since NAALADase hydrolyzes N-acetylaspartylglutamate (NAAG) to glutamate we hypothesized that inhibiting NAALADase would both decrease glutamate and increase NAAG. Increasing NAAG is potentially important because NAAG is a metabotropic glutamate receptor agonist and an N-methyl-D-aspartate… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Pharmacological enhancement of neuronal survival.

Critical reviews in toxicology • 2008
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…