N-Acetyl Cysteine as a Glutathione Precursor for Schizophrenia—A Double-Blind, Randomized, Placebo-Controlled Trial

@article{Berk2008NAcetylCA,
  title={N-Acetyl Cysteine as a Glutathione Precursor for Schizophrenia—A Double-Blind, Randomized, Placebo-Controlled Trial},
  author={M. Berk and D. Copolov and O. Dean and Kristy Lu and A. Bush},
  journal={Biological Psychiatry},
  year={2008},
  volume={64},
  pages={361-368}
}
  • M. Berk, D. Copolov, +2 authors A. Bush
  • Published 2008
  • Medicine
  • Biological Psychiatry
  • BACKGROUND Brain glutathione levels are decreased in schizophrenia, a disorder that often is chronic and refractory to treatment. N-acetyl cysteine (NAC) increases brain glutathione in rodents. This study was conducted to evaluate the safety and effectiveness of oral NAC (1 g orally twice daily [b.i.d.]) as an add-on to maintenance medication for the treatment of chronic schizophrenia over a 24-week period. METHODS A randomized, multicenter, double-blind, placebo-controlled study. The primary… CONTINUE READING

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