N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein

@inproceedings{Liu2017N6,
  title={
N
6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein},
  author={Nian Liu and Katherine I Zhou and Marc Parisien and Qing Dai and Luda Diatchenko and Tao Pan},
  booktitle={Nucleic acids research},
  year={2017}
}
N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic messenger RNA (mRNA), and affects almost every stage of the mRNA life cycle. The YTH-domain proteins can specifically recognize m6A modification to control mRNA maturation, translation and decay. m6A can also alter RNA structures to affect RNA-protein interactions in cells. Here, we show that m6A increases the accessibility of its surrounding RNA sequence to bind heterogeneous nuclear ribonucleoprotein G (HNRNPG… CONTINUE READING
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