N-3 polyunsaturated fatty acids increase hepatic fibroblast growth factor 21 sensitivity via a PPAR-γ-β-klotho pathway.

@article{Yang2017N3PF,
  title={N-3 polyunsaturated fatty acids increase hepatic fibroblast growth factor 21 sensitivity via a PPAR-γ-β-klotho pathway.},
  author={Wenqi Yang and Xu Chen and Yan Liu and Ming Chen and Xinwei Jiang and Tianran Shen and Qing Li and Yan Yang and Wenhua Ling},
  journal={Molecular nutrition & food research},
  year={2017},
  volume={61 9}
}
SCOPE Fibroblast growth factor 21 (FGF21) participated in fish oil-mediated hepatic lipid-regulation and anti-inflammatory effects in high-fat diet fed-mice. However, fish oil supplementation did not significantly increase FGF21 protein levels. Whether fish oil-induced benefits in the liver are related to hepatic FGF21 sensitivity remains unclear. METHODS AND RESULTS Male C57BL/6J mice were fed a low-fat diet (LFD), a high-fat diet (HFD) or a fish oil-supplemented high-fat diet (FOD) for 12… CONTINUE READING
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