N-3 PUFAs reduce oxidative stress in ESRD patients on maintenance HD by inhibiting 5-lipoxygenase activity.

@article{TacconeGallucci2006N3PR,
  title={N-3 PUFAs reduce oxidative stress in ESRD patients on maintenance HD by inhibiting 5-lipoxygenase activity.},
  author={Massimo Taccone-Gallucci and Simone Manca-di-Villahermosa and Luca Battistini and Roberto Giacominelli Stuffler and Marino Jos{\'e} Tedesco and Mauro Maccarrone},
  journal={Kidney international},
  year={2006},
  volume={69 8},
  pages={
          1450-4
        }
}
Reactive oxygen species formation and release of pro-inflammatory/pro-atherogenic cytokines, that is, interleukin 1-beta and tumor necrosis factor-alpha, need the activation of the arachidonic acid cascade via the enzyme 5-lipoxygenase (5-Lox). 5-Lox activity and expression are significantly increased in peripheral blood mononuclear cells (PBMCs) of end-stage renal disease (ESRD) patients on maintenance hemodialysis (HD). Diets enriched with n-3 polyunsaturated fatty acids (PUFAs) (omega-3… CONTINUE READING
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