N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders.

@article{Nedelcovych2017NPivaloyloxyalkoxycarbonylPO,
  title={N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders.},
  author={Michael T. Nedelcovych and Luk{\'a}{\vs} Tenora and Boe-Hyun Kim and Jennifer Kelschenbach and Wei Chao and Eran Hadas and Andrej Jan{\vc}ař{\'i}k and Eva Prchalov{\'a} and Sarah C. Zimmermann and Ranjeet Prasad Dash and Alexandra J Gadiano and Caroline Alice Garrett and Georg J. Furtm{\"u}ller and Byoungchol Oh and Gerald Brandacher and Jesse Alt and Pavel Majer and David J. Volsky and Rana Rais and Barbara S Slusher},
  journal={Journal of medicinal chemistry},
  year={2017},
  volume={60 16},
  pages={7186-7198}
}
Aberrant excitatory neurotransmission associated with overproduction of glutamate has been implicated in the development of HIV-associated neurocognitive disorders (HAND). The glutamine antagonist 6-diazo-5-oxo-l-norleucine (DON, 14) attenuates glutamate synthesis in HIV-infected microglia/macrophages, offering therapeutic potential for HAND. We show that… CONTINUE READING