N-(4-hydroxyphenyl) retinamide is cytotoxic to melanoma cells in vitro through induction of programmed cell death.

@article{Montaldo1999N4hydroxyphenylRI,
  title={N-(4-hydroxyphenyl) retinamide is cytotoxic to melanoma cells in vitro through induction of programmed cell death.},
  author={Paolo Giuseppe Montaldo and Gabriella Pagnan and Fabio Pastorino and Valeria Chiesa and Lizzia Raffaghello and Marc Kirchmeier and Theresa M. Allen and Mirco Ponzoni},
  journal={International journal of cancer},
  year={1999},
  volume={81 2},
  pages={262-7}
}
Melanoma is a highly malignant and increasingly common tumour. Since metastatic melanoma remains incurable, new treatment approaches are needed. Previously, we reported that the synthetic retinoid N-(4-hydroxyphenyl)retinamide (fenretinide, HPR) induces apoptosis in neuroblastoma cells, sharing a neuroectodermal origin with melanoma cells. Since no data exist thus far on the effects of HPR on human melanoma tumours, our purpose was to investigate the in vitro modulation of cell growth and… CONTINUE READING