N-(1-carbamoyl-2-phenylethyl) butyramide reduces antibiotic-induced intestinal injury, innate immune activation and modulates microbiota composition

@article{Lama2019N1carbamoyl2phenylethylBR,
  title={N-(1-carbamoyl-2-phenylethyl) butyramide reduces antibiotic-induced intestinal injury, innate immune activation and modulates microbiota composition},
  author={Adriano Lama and Chiara Annunziata and Lorena Coretti and Claudio Pirozzi and Francesca Di Guida and Allegra Nitrato Izzo and Claudia Cristiano and Maria Pina Mollica and Lorenzo Chiariotti and Alessandra Pelagalli and Francesca Lembo and Rosaria Meli and Giuseppina Mattace Raso},
  journal={Scientific Reports},
  year={2019},
  volume={9}
}
The use/misuse of antibiotics leads to pathological features referring to antibiotic-induced intestinal injury (AIJ), a clinical issue that plays a prominent role in the development of severe digestive disturbances. AIJ is characterized by loss of intestinal architecture and function, dysbiosis and bacterial translocation into the liver, triggering hepatic inflammation. This study aimed at determining the beneficial effect of N-(1-carbamoyl-2-phenylethyl) butyramide (FBA), a butyrate releasing… Expand

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