N-(6,7-dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-alkylsulfonamides as peripherally restricted N-methyl-D-aspartate receptor antagonists for the treatment of pain.

@article{Deur2007N67dichloro23dioxo1234tetrahydroquino,
  title={N-(6,7-dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-alkylsulfonamides as peripherally restricted N-methyl-D-aspartate receptor antagonists for the treatment of pain.},
  author={Christopher Deur and Arun K. Agrawal and Heidi Baum and J Ashley T Booth and Susan Bove and Joan K. Brieland and Amy Bunker and Cleo J Connolly and Joseph A. Cornicelli and J Dumin and Barry C. Finzel and Xinmin Gan and Sheila Guppy and Gregg M Kamilar and Kenneth S Kilgore and Pil Goo Lee and Cho-Ming Loi and Zhen Lou and Mark Morris and Laurence Philippe and Sally A. Przybranowski and Frank E Riley and Brian M Samas and Brian Sanchez and Haile Tecle and Ziqiang Wang and Kathryn A Welch and Michael Wilson and Karen Yates},
  journal={Bioorganic & medicinal chemistry letters},
  year={2007},
  volume={17 16},
  pages={4599-603}
}
It has been hypothesized that peripherally restricted NMDA receptor antagonists may be effective analgesics for osteoarthritis pain. A class of novel quinoxalinedione atropisomers, first discovered for an NMDA receptor antagonist program for the treatment of stroke, was evaluated and further optimized with the goal of finding peripherally restricted NMDA receptor antagonists. 

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