N-(3-Substituted-benzylidene-2-oxoindolin-5-yl)acetamide Derivatives as Src Kinase Inhibitors: Synthesis, Biological Evaluation and Molecular Docking Studies

  • Published 2015


The synthesis of new N-(3-substituted-benzylidene-2-oxoindolin-5-yl) acetamide (5-14) derivatives along with their inhibitory activity against Src is reported. Among all compounds, only 10, 12 and 13 were found slightly active against Src with IC50 values of 3.55, 6.39 and 7.29 mM, respectively. Docking studies have been also performed to analyze the… (More)


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