N-(3,5-Dichlorophenyl)succinimide nephrotoxicity in the Fischer-344 rat.

  title={N-(3,5-Dichlorophenyl)succinimide nephrotoxicity in the Fischer-344 rat.},
  author={Gary O. Rankin and David J. Yang and K Cressey-Veneziano and Patrick I Brown},
  journal={Toxicology letters},
  volume={24 1},
The nephrotoxic potential of N-(3,5-dichlorophenyl)succinimide (NDPS) was examined, in male Fischer-344 rats. Rats were administered NDPS (0.1, 0.2, 0.4 or 1.0 mmol/kg intraperitoneally (i.p.) or sesame oil (2.5 ml/kg, i.p.), and renal function was monitored at 24 and 48 h. NDPS (0.1 mmol/kg) stimulated organic ion uptake at 48 h. NDPS (0.2 mmol/kg) produced diuresis but did not alter blood urea nitrogen (BUN), kidney weight or organic ion uptake by renal cortical slices at 48 h. High-dose NDPS… CONTINUE READING