N-(2-mercaptopropionyl)-glycine but not allopurinol prevented cigarette smoke-induced alveolar enlargement in mouse.

@article{Pires2011N2mercaptopropionylglycineBN,
  title={N-(2-mercaptopropionyl)-glycine but not allopurinol prevented cigarette smoke-induced alveolar enlargement in mouse.},
  author={Karla Maria Pereira Pires and Frank Silva Bezerra and Mariana Nascimento Machado and Walter Ara{\'u}jo Zin and Lu{\'i}s Crist{\'o}v{\~a}o Porto and Samuel Santos Valenca},
  journal={Respiratory physiology & neurobiology},
  year={2011},
  volume={175 3},
  pages={322-30}
}
We investigated the possible protective effects of the Allopurinol (A), N-(2-mercaptopropionyl)-glycine (M) and N-acetylcysteine (N) against lung injury caused by long-term exposure to cigarette smoke (CS) in mouse. C57BL6 mice were exposed to 12 cigarettes a day for 60 days and concomitantly treated with either one of the antioxidant drugs diluted in saline (CS+A-50 mg/kg; CS+M-200 mg/kg/day; CS+N-200 mg/kg/day). Control groups were sham-smoked (AA). Long-term CS exposure results in extensive… CONTINUE READING

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