N-(2-Cyanoethyl)tranylcypromine, a Potential Prodrug of Tranylcypromine: Its Disposition and Interaction with Catecholamine Neurotransmitters in Brain

@article{Nazarali1987N2CyanoethyltranylcypromineAP,
  title={N-(2-Cyanoethyl)tranylcypromine, a Potential Prodrug of Tranylcypromine: Its Disposition and Interaction with Catecholamine Neurotransmitters in Brain},
  author={Adil J. Nazarali and Glen B Baker and Ronald Thomson Coutts and T. F. James Wong},
  journal={Pharmaceutical Research},
  year={1987},
  volume={4},
  pages={16-20}
}
The disposition of the N-cyanoethyl analogue of tranylcypromine (TCP) and the TCP formed from it have been studied in the rat brain following intraperitoneal (ip) administration (0.1 mmol/kg) and the resultant data compared with those obtained following an equimolar dose of TCP. Brain concentrations of the neurotransmitter amines dopamine (DA) and noradrenaline (NA) have also been determined, as well as the percentage inhibition of monoamine oxidase (MAO) types A and B. Our results indicate… CONTINUE READING