N–Methyl–D–aspartate antagonists limit aminoglycoside antibiotic–induced hearing loss

@article{Basile1996NMethylDaspartateAL,
  title={N–Methyl–D–aspartate antagonists limit aminoglycoside antibiotic–induced hearing loss},
  author={Anthony S. Basile and Jer-Min Huang and Chen Xie and Douglas B. Webster and Charles I. Berlin and Phil Skolnick},
  journal={Nature Medicine},
  year={1996},
  volume={2},
  pages={1338-1343}
}
The use of aminoglycoside antibiotics is limited by ototoxicity that can produce permanent hearing loss. We report that concurrent administration of N–methyl–D–aspartate (NMDA) antagonists markedly attenuates both the hearing loss and destruction of cochlear hair cells in guinea pigs treated with aminoglycoside antibiotics. These findings indicate that aminoglycoside–induced hearing loss is mediated, in part, through an excitotoxic process. The high correlation (Spearman correlation coefficient… 
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  • 2000
TLDR
Evidence is accumulating to suggest that many aminoglycosides cause excitotoxicity in hair cells as a result of their agonist action at the polyamine site on the N- methyl-D-aspartate (NMDA) receptor, and the therapeutic implications of this hypothesis are considered.
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    Current pharmaceutical design
  • 2007
TLDR
In this paper, incidence, predisposition, mechanism, and prevention of aminoglycoside-induced ototoxicity is discussed in the light of literature data.
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