N–Methyl–D–aspartate antagonists limit aminoglycoside antibiotic–induced hearing loss

  title={N–Methyl–D–aspartate antagonists limit aminoglycoside antibiotic–induced hearing loss},
  author={A. Basile and Jer-Min Huang and C. Xie and D. Webster and C. Berlin and P. Skolnick},
  journal={Nature Medicine},
  • A. Basile, Jer-Min Huang, +3 authors P. Skolnick
  • Published 1996
  • Medicine
  • Nature Medicine
  • The use of aminoglycoside antibiotics is limited by ototoxicity that can produce permanent hearing loss. We report that concurrent administration of N–methyl–D–aspartate (NMDA) antagonists markedly attenuates both the hearing loss and destruction of cochlear hair cells in guinea pigs treated with aminoglycoside antibiotics. These findings indicate that aminoglycoside–induced hearing loss is mediated, in part, through an excitotoxic process. The high correlation (Spearman correlation coefficient… CONTINUE READING
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