N‐methyl‐D‐aspartate receptor antibodies in herpes simplex encephalitis

@article{Prss2012NmethylDaspartateRA,
  title={N‐methyl‐D‐aspartate receptor antibodies in herpes simplex encephalitis},
  author={Harald Pr{\"u}ss and Carsten Finke and Markus H{\"o}ltje and Joerg Hofmann and Christine Klingbeil and Christian P. Probst and Kathrin Borowski and Gudrun Ahnert-Hilger and Lutz Harms and Jan M. Schwab and Christoph J. Ploner and Lars Komorowski and Winfried Stoecker and Josep Dalmau and Klaus-Peter Wandinger},
  journal={Annals of Neurology},
  year={2012},
  volume={72}
}
To determine the presence and kinetics of antibodies against synaptic proteins in patients with herpes simplex virus encephalitis (HSE). 
Herpes simplex virus‐induced anti‐N‐methyl‐d‐aspartate receptor encephalitis: a systematic literature review with analysis of 43 cases
To conduct a systematic literature review on patients with biphasic disease with herpes simplex virus (HSV) encephalitis followed by anti‐N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis.
Herpes simplex encephalitis relapse with chorea is associated with autoantibodies to N‐Methyl‐D‐aspartate receptor or dopamine‐2 receptor
TLDR
A proportion of patients with HSV1 encephalitis (HSE) were shown to produce autoantibodies against N‐methyl‐D‐aspartate receptor (NMDAR) when treated with NMDAR, suggesting postviral autoimmunity may be a factor in relapses. Expand
Anti-NMDA Receptor Encephalitis, Autoimmunity, and Psychosis.
(Reprinted with permission from Schizophrenia Research 2013; 176:36-40).
High prevalence of NMDA receptor IgA/IgM antibodies in different dementia types
TLDR
To retrospectively determine the frequency of N‐Methyl‐D‐Aspartate (NMDA‐aspartate) receptor (NMDAR) autoantibodies in patients with different forms of dementia, a retrospective study is conducted. Expand
N‐methyl‐D‐aspartate receptor antibody production from germinal center reactions: Therapeutic implications
TLDR
Despite clear therapeutic relevance, mechanisms of NR1‐IgG production and the contribution of germinal center B cells to NR1 `G’ levels are unknown. Expand
Anti-N-Methyl-D-Aspartate Receptor Antibody Mediated Neurologic Relapse Post Herpes Simplex Encephalitis: A Case Series.
TLDR
This work presents 3 cases of neurologic relapse after herpes simplex encephalitis, discusses diagnostic and management dilemmas and reports on inflammation caused by anti-N-methyl-D-aspartate receptor antibodies. Expand
A Case of Anti-N-Methyl-D-Aspartate Receptor Encephalitis Triggered by Herpes Simplex Virus Encephalitis
TLDR
A case of Anti-NMDAR encephalitis after HSE who with movement disorders, autonomic nervous dysfunction and extreme delta brush (EDB) in electroencephalogram (EEG). Expand
Anti‐N‐methyl‐D‐aspartate receptor encephalitis and Epstein‐Barr virus: another tale on autoimmunity?
TLDR
A patient with symptoms compatible with Epstein-Barr virus (EBV) primary infection who developed antiNMDARE and positive cerebrospinal fluid (CSF) EBV-polymerase chain reaction (PCR) is described. Expand
Anti-NMDA Receptor antibody encephalitis with concomitant detection of Varicella zoster virus.
  • N. Solís, L. Salazar, R. Hasbún
  • Medicine
  • Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • 2016
TLDR
This case describes a classic presentation of anti-NMDA receptor encephalitis with the concomitant presence of Varicella zoster virus in the cerebrospinal fluid. Expand
Herpesvirus Infection and Immunity in Neurocognitive Disorders
Herpesviruses have co-speciated with several vertebrate and invertebrate animals throughout the history of evolution. In the immunocompetent human host, primary infection is usually benign, whereafExpand
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TLDR
The authors report data on six children who had at least one relapse of HSE, finding that relapses with viral replication may reveal host susceptibility to herpes simplex virus infection. Expand
Anti-NMDA-receptor encephalitis: A severe, multistage, treatable disorder presenting with psychosis
TLDR
Indirect immunofluorescence using NMDA-type glutamate receptors recombinantly expressed in human cells is a highly competent method for diagnosing anti-NMDA-receptor encephalitis. Expand
Anti-NMDA receptor encephalitis: report of ten cases and comparison with viral encephalitis
TLDR
Comparing the presentation of patients with N-methyl-D-aspartate receptor (NMDAR) antibodies to those with viral encephalitis is compared, so that infectious disease clinicians may identify individuals with this treatable disorder. Expand
Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies
TLDR
A well-defined set of clinical characteristics are associated with anti-NMDA-receptor encephalitis and the pathogenesis of the disorder seems to be mediated by antibodies. Expand
The frequency of autoimmune N-methyl-D-aspartate receptor encephalitis surpasses that of individual viral etiologies in young individuals enrolled in the California Encephalitis Project.
TLDR
The relative frequency and differences among encephalitides caused by anti-NMDAR and viral etiologies within the CEP experience are reported to avoid unnecessary diagnostic and treatment costs, and to permit a more timely treatment. Expand
Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis
TLDR
Patients' antibodies cause a titre-dependent, reversible decrease of synaptic NMDAR by a mechanism of crosslinking and internalisation, which reveals a probable pathogenic relation between the depletion of receptors and the clinical features of anti-NMDAR encephalitis. Expand
Retrospective analysis of NMDA receptor antibodies in encephalitis of unknown origin
TLDR
Six of 7 cases with the indicated clinical criteria had anti-NMDAR encephalitis, which represented 1% of all young patients' admissions to the ICU, and NMDAR antibodies should be tested in all patients withEncephalitis who fulfill these criteria. Expand
Anti-N-methyl-D-aspartate receptor antibodies: A potentially treatable cause of encephalitis in the intensive care unit
TLDR
N-methyl-D-aspartate receptor antibodies should be tested in patients with hyperkinetic encephalitis and neuropsychiatric prodrome admitted to the intensive care unit, because the disorder is probably not rare and is potentially treatable. Expand
In vivo effects of antibodies from patients with anti-NMDA receptor encephalitis: further evidence of synaptic glutamatergic dysfunction
TLDR
Evidence in vivo is provided that NMDA-R antibodies deregulate the glutamatergic pathways and that the encephalitis associated with these antibodies is an auto-immune synaptic disorder. Expand
The neurotropic herpes viruses: herpes simplex and varicella-zoster
TLDR
The biological, medical, and neurological aspects of acute, latent, and reactivated infections with the neurotropic herpes viruses are reviewed. Expand
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