N‐acetylserotonin is a better extra‐ and intracellular antioxidant than melatonin

@article{Wlfler1999NacetylserotoninIA,
  title={N‐acetylserotonin is a better extra‐ and intracellular antioxidant than melatonin},
  author={Albert W{\"o}lfler and Peter M. Abuja and Konrad Schauenstein and Peter. Liebmann},
  journal={FEBS Letters},
  year={1999},
  volume={449}
}

N-acetylserotonin reduces lipopolysaccharide-induced lipid peroxidation in vitro more effectively than melatonin.

TLDR
The results of the reported study clearly indicate that N-acetylserotonin is a much stronger antioxidant in vitro than melatonin in terms of reducing oxidative damage to lipid membranes, but it remains still unclear how the features relate to in vivo circumstances.

Antioxidant Effects of N‐Acetylserotonin

TLDR
Antioxidant effect of NAS might underpin its cognition‐enhancing, antiaging, antidepressant, antihypertensive, and antitumor effects and might be useful in protection against oxidative stress‐related disorders and diseases.

6-methoxytryptophol reduces lipopolysaccharide-induced lipid peroxidation in vitro more effectively than melatonin.

TLDR
The results of the reported study indicate that 6-methoxytryptophol is a much stronger antioxidant in vitro than melatonin in terms of reducing oxidative damage to lipid membranes, however, it remains still unclear how the features relate to in vivo circumstances.

Hydroxyl radical scavenging activity of melatonin and its related indolamines

TLDR
Calculations show that melatonin is the most effective radical scavenger among the three molecules chosen, which implies that non-natural derivatives of indolamines might as well be useful in the detoxification of free radicals as they exhibit almost comparable antioxidant efficiency as that of melatonin.

Antioxidant effects of N-acetylserotonin: possible mechanisms and clinical implications.

  • G. Oxenkrug
  • Biology
    Annals of the New York Academy of Sciences
  • 2005
TLDR
Antioxidant effect of NAS might underpin its cognition-enhancing, antiaging, antidepressant, antihypertensive, and antitumor effects and might be useful in protection against oxidative stress-related disorders and diseases.

Can melatonin delay oxidative damage of human erythrocytes during prolonged incubation?

TLDR
Probably, MEL can stabilize the erythrocyte membrane due to interaction with lipids, thus prolonging the existence of cells, and in the presence of MEL the accelerated oxidation of HbO₂ and generally, increased oxidative stress was observed in ery Throcytes.
...

References

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N‐acetyl‐serotonin (normelatonin) and melatonin protect neurons against oxidative challenges and suppress the activity of the transcription factor NF‐κB

TLDR
Normelatonin's and melatonin's neuroprotective activity in SK‐N‐MC neuroblastoma cells may be mediated by the suppression of NF‐κB activation, and normelatonin was more potent in the suppressing of the activation of NF-κB by H2O2 in SK-N-MC cells compared to melatonin, no apparent differences in the extent of suppression could be detected in primary neurons.

Effect of melatonin and metabolites on copper-mediated oxidation of flow density lipoprotein.

TLDR
The present results indicate that the pineal hormone melatonin appears to have little antiatherogenic property as regards the oxidation of LDL, however, its main breakdown product 6-hydroxymelatonin inhibits LDL-oxidation comparable to vitamin E.

Inhibition of LDL oxidation by melatonin requires supraphysiologic concentrations.

TLDR
extremely supraphysiologic concentrations of melatonin had only weak antioxidant activity, which was surpassed by alpha-tocopherol, ascorbic acid, and tryptophan, which were significantly more potent than melatonin.

Melatonin biosynthesis and metabolism in peripheral blood mononuclear leucocytes.

Cultured human peripheral blood mononuclear leucocytes (PBML) were able to synthesize indoleamines, including melatonin, and were also able to convert melatonin taken up from the incubation medium

Melatonin Its intracellular and genomic actions

Inhibition of lipid peroxidation by N-acetylserotonin and its role in retinal physiology.

TLDR
N-Acetylserotonin reduces the rate of ABAP-initiated lipid peroxidation in a concentration-dependent manner, and it is suggested that NAS acts as a physiological antioxidant in retinal photoreceptor cells.