N‐acetylcysteine ethyl ester as GSH enhancer in human primary endothelial cells: A comparative study with other drugs

@article{Giustarini2018NacetylcysteineEE,
  title={N‐acetylcysteine ethyl ester as GSH enhancer in human primary endothelial cells: A comparative study with other drugs},
  author={D. Giustarini and F. Galvagni and Isabella Dalle Donne and A. Milzani and F. Severi and A. Santucci and R. Rossi},
  journal={Free Radical Biology and Medicine},
  year={2018},
  volume={126},
  pages={202–209}
}
  • D. Giustarini, F. Galvagni, +4 authors R. Rossi
  • Published 2018
  • Chemistry, Medicine
  • Free Radical Biology and Medicine
  • Abstract Several drugs are currently in use as glutathione (GSH) enhancers in clinical, pre‐clinical and experimental research. Here we compare the ability of N‐acetylcysteine (NAC), 2‐oxothiazolidine‐4‐carboxylic acid (OTC), glutathione ethyl ester (GSH‐EE) and N‐acetylcysteine ethyl ester (NACET) to increase the intracellular concentration of GSH using primary human umbilical vein endothelial cells (HUVEC) as in vitro model. Our experiments highlighted that NACET is largely the most efficient… CONTINUE READING

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